When it comes to bupropion, a norepinephrine-dopamine reuptake inhibitor (NDRI) used to treat depression and aid smoking cessation. Also known as Wellbutrin, it stands out because it doesn’t typically cause the sexual side effects that plague other antidepressants. In fact, for many men, bupropion might actually improve sexual function—something few other meds can claim. While SSRIs like sertraline or fluoxetine often lead to low libido, delayed orgasm, or erectile problems, bupropion works differently. It boosts dopamine and norepinephrine, two brain chemicals tied to arousal, motivation, and pleasure. That’s why some doctors prescribe it specifically for men struggling with sexual dysfunction caused by other antidepressants—or even for those with low libido and no depression.
Sexual dysfunction isn’t just about erections. It includes lack of desire, trouble getting or keeping an erection, and delayed or absent orgasm. Many men assume these issues are normal with age or stress. But when they start after beginning an antidepressant, the link is often clear. Studies show up to 70% of men on SSRIs report sexual side effects. Bupropion, however, has been shown in clinical trials to improve sexual function in up to 60% of men who switched from SSRIs to it. One 2015 study in the Journal of Clinical Psychiatry found that men on bupropion reported better sexual satisfaction than those on fluoxetine. It’s not a magic pill for everyone, but for men whose sex life tanked after starting an antidepressant, it’s often the first real solution.
It’s important to know bupropion isn’t FDA-approved specifically for sexual dysfunction. But that doesn’t mean it’s not used for it—off-label prescribing is common and well-supported in medical practice. Doctors often try it when other options fail. It also works well for men with low energy or brain fog, which can drag down sexual interest. And unlike PDE5 inhibitors like Viagra, which target blood flow, bupropion works from the inside out—on the brain’s reward system. That’s why some men notice improved libido before any physical changes. But it’s not risk-free. Seizures are rare but possible, especially at high doses or if you have a history of seizures or eating disorders. It can also raise blood pressure, so regular checkups matter.
If you’re on an antidepressant and your sex life has suffered, you’re not alone. And you don’t have to just live with it. Bupropion offers a real alternative—backed by data, not just theory. Below, you’ll find real-world insights from posts that dig into how medications affect sexual health, what alternatives exist, and how to talk to your doctor about switching safely. No guesswork. Just clear, practical info to help you take control.
Learn how adding a second medication - not switching - can fix common antidepressant side effects like insomnia, sexual dysfunction, and weight gain. Evidence-based strategies that actually work.